How supraphysiological preconditioning™ works
By gently warming the skin, BLOOM43 causes the release of a special group of naturally occurring proteins within the body’s cells called ‘Heat Shock Proteins’ or HSPs. These protective proteins help our cells maintain their normal function. In particular, HSP-32 triggers the natural release of carbon monoxide into the surrounding tissue.
Carbon monoxide is a highly effective vasodilator, making blood vessels open up and increasing blood flow to the area.
And better blood flow means better healing.
50%
Reduced reoperation rates
70%
Reduced outpatient follow up
24%
Absolute Risk Reduction (ARR) of skin necrosis
Clinical trials demonstrate measurable increases in skin blood flow with supraphysiological preconditioning™
Sometimes, following breast surgery, patients may experience problems such as wound breakdown. This is often due to the disturbance of blood vessels supplying the skin during the operation. Depending on the extent of the wound complication, some patients may require further surgery, with longer hospital stays and frequent clinic appointments.
Prospective clinical trials* have shown that thermal preconditioning is a simple and non-invasive method of reducing skin necrosis and length of hospital stay following breast surgery. The research studies demonstrated that supraphysiological preconditioning™ reduced the rate of skin necrosis by 24% (absolute risk reduction) and the need for further surgery by 50%.
BLOOM⁴³ has been developed as a simple, drug-free wearable device for home use. Worn for a few hours the night before surgery, it offers the benefits of supraphysiological preconditioning™ with precision and ease.
Right breast
Left breast
The laser doppler scan shows the increased blood flow to the right preconditioned breast compared to the left non-preconditioned breast.
*Sources: “Local Heat Preconditioning in Skin Sparing Mastectomy: A Pilot Study”, Mehta S, Rolph R, Cornelius V et al., 2013; “A Randomised Controlled Feasibility Trial to Evaluate Local Heat Preconditioning on Wound Healing After Reconstructive Breast Surgery: The preHEAT Trial.”, Mehta S, Cro SC, Coomber B et al., 2019.Our Studies
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Authors: Kankam HKN et al.
Journal of Plastic, Reconstructive & Aesthetic Surgery, 2020
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Authors: Mehta S et al.
Pilot and Feasibility Studies, 2019
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Authors: Mehta S et al.
Journal of Plastic, Reconstructive & Aesthetic Surgery, 2013
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Authors: Freer F et al.
Status: Under peer review
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Authors: Arif T et al.
Under peer review
Ongoing research
Scientific research: PRECONDITIONING
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Authors: Harder Y. et al.
Annals of Surgery, 2005
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Authors: Harder Y. et al.
Journal of Surgical Research, 2004
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Authors: Rücker M et al.
British Journal of Surgery, 2001
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Authors: Wang BH et al.
Plastic and Reconstructive Surgery, 1998
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Authors: Koenig WJ et al.
Plastic and Reconstructive Surgery, 1992
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Authors: Hou P et al.
Journal of Thermal Biology, 2023
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Authors: Baumeister S et al.
Plastic and Reconstructive Surgery, 2004
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Authors: Rücker M et al.
Surgery, 2001
Scientific research: PREHABILITATION
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Authors: Bilku DK et al.
Annals of the Royal College of Surgeons of England, 2014
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Authors: Niklasson A et al.
Sleep Medicine Reviews, 2025
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Authors: Zielińska M et al.
International Journal of Molecular Sciences, 2023
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Authors: Hirsch KR et al.
Nutrients, 2021
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Authors: Banugo P et al.
The British Journal of Anaesthesia, 2017
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Authors: Thomsen T et al.
British Journal of Surgery, 2009
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Authors: McIsaac DI et al.
British Medical Journal, 2025
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Authors: Singh F et al.
Surgical Oncology, 2013
