How supraphysiological preconditioning™ works
By gently warming the skin, BLOOM43 causes the release of a special group of naturally occurring proteins within the body’s cells called ‘Heat Shock Proteins’ or HSPs. These protective proteins help our cells maintain their normal function. In particular, HSP-32 triggers the natural release of carbon monoxide into the surrounding tissue.
Carbon monoxide is a highly effective vasodilator, making blood vessels open up and increasing blood flow to the area.
And better blood flow means better healing.
50%
Reduced reoperation rates
70%
Reduced outpatient follow up
13%
Reduced healing complications
2 days
Reduced hospital stay
Based on prospective trials and peer-reviewed papers
Local heat preconditioning in skin sparing mastectomy: A pilot study
S Mehta, et al. Journal of Plastic, Reconstructive & Aesthetic Surgery (September, 2013)
A randomised controlled feasibility trial to evaluate local heat preconditioning on wound healing after reconstructive breast surgery: the preHEAT trial
S Mehta, et al. Pilot Feasibility Studies
(January, 2019)
Thermal Preconditioning for Surgery: A Systematic Review
H Kankam, et al. Journal of Plastic, Reconstructive & Aesthetic Surgery (May, 2020)
Clinical trials demonstrate measurable increases in skin blood flow with supraphysiological preconditioning™.
Sometimes following breast surgery, patients may experience problems such as wound breakdown. This is often due to the disturbance of blood vessels supplying the skin during the operation. Depending on the extent of the wound complication, some patients may require further surgery, with longer hospital stays and frequent clinic appointments.
In a prospective non-randomised trial involving 50 patients, it was shown that local heat preconditioning is a simple and non-invasive method of reducing skin necrosis and length of hospital stay following breast surgery. The research demonstrated that this supraphysiological preconditioning™ technique reduced the rate of wound healing complications by 9%, the need for further surgery by 50% and hospital stays by 2 days.
BLOOM43 has been developed as a simple, drug-free wearable device for home use. Worn for a few hours the night before surgery, it offers the benefits of supraphysiological preconditioning™ with precision and ease. Heating the breast initiates the body’s in-built healing mechanisms, increasing blood flow and the release of ‘Heat Shock Proteins’ which support wound healing.
Better blood flow means better healing.
The laser doppler scan shows the increased blood flow to the right pre-heated breast (top image) compared to the left non-heated breast (bottom image).